منابع مشابه
Release behavior of alkyl-p-aminobenzoate esterâ•fiPVP solid dispersions
Solid polymer-drug dispersions are used to prepare and stabilize amorphous forms of poorly soluble drugs as a means of improving drug solubility, dissolution and bioavailability. Despite many reports on this subject, solid dispersion dissolution mechanisms have not been well understood. An early study was reported by Simonelli, Mehta and Higuchi (SMH) in 1969 and has served as a model for dispe...
متن کاملIn vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis.
p-Aminobenzoate N-oxygenase (AurF) from Streptomyces thioluteus catalyzes the formation of unusual polyketide synthase starter unit p-nitrobenzoic acid (pNBA) from p-aminobenzoic acid (pABA) in the biosynthesis of antibiotic aureothin. AurF is a metalloenzyme, but its native enzymatic activity has not been demonstrated in vitro, and its catalytic mechanism is unclear. In addition, the nature of...
متن کاملThe nutritional equivalence of pantothenate and p-aminobenzoate for the growth of Bacterium linens.
Knowledge concerning the function of paminobenzoate in biological systems has been derived largely by the use of specificcompetitive inhibitors. Thus, the reversal of either sulfanilamide or 2-chloro4-aminobenzoate inhibition by methionine and other amino acids (Lampen et al., 1946; King et al., 1948; Strandskov, 1947; Winkler and DeHaan, 1948), by pteroylglutamic acid (Nimmo-Smith et al., 1948...
متن کاملp-Aminobenzoate biosynthesis in Escherichia coli. Purification of aminodeoxychorismate lyase and cloning of pabC.
p-Aminobenzoate, a component of the vitamin folate, is one of seven compounds derived from the aromatic precursor chorismate in Escherichia coli. Historically the gene products of pabA and pabB were assumed to be sufficient for de novo p-aminobenzoate biosynthesis. Recent studies, however, have shown that these proteins, as nonidentical subunits of a single enzyme, act on chorismate to form a d...
متن کاملThe folate precursor p-aminobenzoate is reversibly converted to its glucose ester in the plant cytosol.
Plants synthesize p-aminobenzoate (pABA) in chloroplasts and use it for folate synthesis in mitochondria. It has generally been supposed that pABA exists as the free acid in plant cells and that it moves between organelles in this form. Here we show that fruits and leaves of tomato and leaves of a diverse range of other plants have a high capacity to convert exogenously supplied pABA to its bet...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1975
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.123.3.1131-1138.1975